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Journal articles
Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE.
M. A. Rodger
1, 2, *
Grégoire Le Gal
3, 4
Marc Carrier
2
M. T. Betancourt
1, 2
S. R. Kahn
5, 6
P. S. Wells
1, 2
D. A. Anderson
7
Karine Lacut
3, 4
I. Chagnon
8
S. Solymoss
6
M. Crowther
9
A. Perrier
10
R. White
11
L. Vickars
12
T. Ramsay
1, 2
M. J. Kovacs
13
*
Corresponding author
M. A. Rodger 1, 2
Correspondent author
Grégoire Le Gal 3, 4
Author
Marc Carrier 2
Author
M. T. Betancourt 1, 2
Author
1
Thrombosis Program (Division of Hematology Department of Medicine - Canada)
- University of Ottawa [Ottawa] (75 Laurier Avenue East, Ottawa, ON K1N 6N5 - Canada)
2
Clinical Epidemiology Unit (Ottawa Hospital Research Institute - Canada)
- Ottawa (France)
- The Ottawa Hospital (France)
3
GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale (CHU de la Cavale Blanche Département de médecine interne et pneumologie 29609 BREST - France)
- UBO - Université de Brest : EA3878 (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
- IBSAM - Institut Brestois Santé Agro Matière (Université de Brest- UBO
29238 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
4
CIC - Brest - Centre d'Investigation Clinique (CHU de la Cavale Blanche 29609 Brest - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : CIC502 (101, rue de Tolbiac, 75013 Paris - France)
5
CCECS - Centre for Clinical Epidemiology and Community Studies (MONTREAL - Canada)
- Jewish General Hospital (Canada)
6
Department of Medecine [Montréal] (McGill University McIntyre Medical Building, 3655 Sir William Osler Montreal, Quebec H3G 1Y6 - Canada)
- McGill University = Université McGill [Montréal, Canada] (845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4 - Canada)
7
Department of Medicine (HALIFAX - Canada)
- Dalhousie University [Halifax] ( 6299 South St, Halifax, NS B3H 4R2 - Canada)
8
DM - HSC Montréal - Department of Medicine (Department of Medicine Hopital du Sacre-Coeur de Montreal University of Montreal Montreal - Canada)
- University of Montreal (France)
9
DM - McMaster - Department of Medicine (Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton - Canada)
- McMaster University [Hamilton, Ontario] (1280 Main Street West Hamilton, Ontario L8S 4L8 - Canada)
10
AP - Department of Internal Medicine (Geneva University Hospital, Geneva, Switzerland - Switzerland)
- HUG - Geneva University Hospital (Switzerland)
11
RW - Department of Medicine (Department of Medicine, UC Davis School of Medicine, Sacramento, CA, USA - United States)
- UC Davis School of Medicine (France)
12
UBC - St Paul Hospital - Department of Medicine (St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada - Canada)
- University of British Colombia (France)
13
MJK - Division of Hematology (Division of Hematology Department of Medicine University of Western Ontario, London - Canada)
- UWO - University of Western Ontario (1151 Richmond St, London, ON, N6A 3K7, Canada - Canada)
Abstract : INTRODUCTION: Case-control studies suggest that elevated lipoprotein (a) (Lp(a)) is a risk factor for first venous thromboembolism (VTE). Lp(a) has not been prospectively investigated as a possible risk factor for recurrent VTE in first unprovoked VTE patients. We sought to determine if serum Lp(a) levels in patients with unprovoked VTE who discontinue anticoagulants after 5 to 7 months of therapy predict VTE recurrence in a prospective cohort study. MATERIALS AND METHODS: Serum Lp(a) measurements were obtained from 510 first unprovoked VTE patients treated for 5 -7 months with anticoagulants in a 12 center study. Patients were subsequently followed for a mean of 16.9 months (SD+/-11.2) for symptomatic VTE recurrence which was independently adjudicated with reference to baseline imaging. RESULTS: There was no significant association between Lp(a) as a continuous variable and recurrent VTE nor in gender stratified subgroups. No statistically significant differences were observed in the median Lp(a) concentrations between patients who recurred and those who did not recur (median (interquartile range): 0.09 g/L (0.17) versus 0.06 g/L (0.11) respectively; p=0.15). The Lp(a) cut-off point of 0.3g/L was not significantly associated with recurrent VTE for the overall population nor in gender stratified subgroups. CONCLUSIONS: Elevated serum Lp(a) does not appear to be associated with recurrent VTE in patients with history of first unprovoked VTE and may not play a role in identifying patients with unprovoked VTE at high risk of recurrence. There was no optimal predictive threshold for the overall population or for sex sub-groups and Lp(a)>or=0.3 g/L was not a significant predictor of recurrent VTE.
Document type :
Journal articles
Domain :
Complete list of metadata
https://hal.univ-brest.fr/hal-00722005
Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Tuesday, July 31, 2012 - 1:16:55 PM
Last modification on : Tuesday, April 19, 2022 - 10:16:23 AM
Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Tuesday, July 31, 2012 - 1:16:55 PM
Last modification on : Tuesday, April 19, 2022 - 10:16:23 AM
Identifiers
- HAL Id : hal-00722005, version 1
- DOI : 10.1016/j.thromres.2010.06.007
- PUBMED : 20580413
Collections
UNIV-BREST | GETBO | IBSAM
Citation
M. A. Rodger, Grégoire Le Gal, Marc Carrier, M. T. Betancourt, S. R. Kahn, et al.. Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE.. Thrombosis Research, Elsevier, 2010, 126 (3), pp.222-6. ⟨10.1016/j.thromres.2010.06.007⟩. ⟨hal-00722005⟩
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