Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence.

A. Hamadah; T. Alwasaidi; Grégoire Le Gal; Marc Carrier; Phil Wells; Dimitrios Scarvelis; Carole Gonsalves; Melissa Forgie; M. J. Kovacs; M. A. Rodger

doi:10.1111/j.1538-7836.2011.04533.x

Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence.

A. Hamadah ¹ T. Alwasaidi ¹ Grégoire Le Gal ^{2, 3} Marc Carrier ^{4, 1} Phil Wells ^{1, 4} Dimitrios Scarvelis ¹ Carole Gonsalves ¹ Melissa Forgie ¹ M. J. Kovacs ⁵ M. A. Rodger ^{1, 4, *}

* Auteur correspondant

1 Thrombosis Program

2 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale

3 CIC - Brest - Centre d'Investigation Clinique

4 Clinical Epidemiology Unit

5 MJK - Division of Hematology

Abstract : BACKGROUND: After a first unprovoked venous thromboembolism (VTE), many patients have residual pulmonary and/or lower limb vascular obstruction following completion of short-term anticoagulation. Residual vascular obstruction may complicate the diagnosis of recurrent VTE. Whether baseline imaging, conducted after completion of anticoagulation, helps in interpreting diagnostic testing in patients who subsequently have suspected recurrent VTE is unknown. STUDY DESIGN: The REVERSE study is a cohort study whose primary aim was to derive a clinical decision rule to guide the duration of anticoagulation after a first unprovoked VTE. All patients underwent baseline imaging after completing 5-7 months of anticoagulant therapy. We performed a post hoc randomized controlled comparison among 121 patients investigated for a suspected recurrent VTE during follow-up: the decision on recurrent VTE with or without baseline imaging was made available to two independent adjudicators. RESULTS: The proportion of patients not classifiable for recurrent VTE was statistically significantly higher in the group with no baseline imaging than in the group with baseline imaging: one in five as compared with one in 25. The interobserver agreement between the two adjudicators was better in the group with baseline imaging than in the group with no baseline imaging: κ-values were 0.78 and 0.54, respectively. CONCLUSIONS: In patients with a first unprovoked VTE, baseline imaging at completion of anticoagulant therapy helps in interpreting diagnostic tests performed in cases of suspected recurrent VTE.

Type de document :

Article dans une revue

Journal of Thrombosis and Haemostasis, Wiley, 2011, 9 (12), pp.2406-10. 〈10.1111/j.1538-7836.2011.04533.x〉

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie

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http://hal.univ-brest.fr/hal-00721933
Contributeur : Ghislaine Calvez <>
Soumis le : mardi 31 juillet 2012 - 10:18:11
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence.

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Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence.

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