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Antipsychotics: A Real or Confounding Risk Factor for Venous Thromboembolism?

C. Chapelle 1 S. Quenet X. Delavenne Karine Lacut 2 P. Mismetti 3 S. Laporte 3 M. N. Beyens
1 GRT (EA 3065) - Groupe de recherche sur la thrombose
2 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
3 Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Saint Etienne
Abstract : In a meta-analysis of case-control studies, Zhang et al. (2011) found an increased risk of venous thromboembolic events (VTE) in patients exposed to antipsychotics (OR=2.39 [1.71-3.35]). Our updated meta-analysis including the 2 available cohort studies, recognized as a more relevant type of observational study, showed a weaker, but still strong association (OR=1.84 [1.39; 2.44]). In view of the lack of data on the confirmed risk factors for VTE in existing studies, prospective studies including adjustment for these risk factors are warranted to confirm this association and to assess the benefit/risk ratio of antipsychotics in high-risk patients.
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https://hal.univ-brest.fr/hal-00720752
Contributor : Ghislaine Calvez <>
Submitted on : Wednesday, July 25, 2012 - 4:20:12 PM
Last modification on : Thursday, November 21, 2019 - 2:38:51 AM

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UNIV-ST-ETIENNE | UNIV-BREST | GETBO | IBSAM | UDL

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C. Chapelle, S. Quenet, X. Delavenne, Karine Lacut, P. Mismetti, et al.. Antipsychotics: A Real or Confounding Risk Factor for Venous Thromboembolism?. Pharmacopsychiatry, Georg Thieme Verlag, 2012, epub ahead of print. ⟨10.1055/s-0032-1316347⟩. ⟨hal-00720752⟩

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