Postmenopausal hormone therapy and cardiovascular disease: an overview of main findings.

Marianne Canonico; Céline Straczek; Emmanuel Oger; Geneviève Plu-Bureau; Pierre-Yves Scarabin

doi:10.1016/j.maturitas.2006.04.019

Postmenopausal hormone therapy and cardiovascular disease: an overview of main findings.

Marianne Canonico ¹ Céline Straczek ^{2, 3} Emmanuel Oger ⁴ Geneviève Plu-Bureau ¹ Pierre-Yves Scarabin ^{1, *}

* Auteur correspondant

1 Recherche en épidémiologie et biostatistique

2 PARCC - U970 - Paris-Centre de Recherche Cardiovasculaire

3 Epidémiologie cardiovasculaire et mort subite

4 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale

Abstract : Cardiovascular disease has emerged as a leading cause of death in women. In recent years, significant attention has been paid to the potential benefits of hormone therapy on chronic diseases such as cardiovascular disease. Large prevention trials failed to confirm the cardioprotective effect of estrogen. The divergent findings from observational and randomized clinical studies are summarized and reasons for the different results are postulated. Use of estrogen alone or estrogen opposed with progestins is not indicated for the prevention of cardiovascular disease and may even increase the risk of stroke. Oral estrogen increases venous thromboembolism events. Recent data suggest that transdermal estrogens are safe with respect to venous thromboembolism. Current data have limited ability to investigate the wide variety of hormone treatments available. Clinical research should be continued to assist patients and clinicians in making treatment decisions on the basis of an individual's benefits and risks.

Type de document :

Article dans une revue

Maturitas, Elsevier, 2006, 54 (4), pp.372-9. 〈10.1016/j.maturitas.2006.04.019〉

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie

Liste complète des métadonnées

http://hal.univ-brest.fr/hal-00689529
Contributeur : Ghislaine Calvez <>
Soumis le : jeudi 19 avril 2012 - 16:23:18
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

Postmenopausal hormone therapy and cardiovascular disease: an overview of main findings.

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