Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study.

Abstract : BACKGROUND: Moderate hyperhomocysteinemia and B vitamins deficiency are thought to be risk factors for venous thromboembolism (VTE). The causality and independence of those associations are still questioned. METHODS: We measured fasting serum total homocysteine, folates, and vitamin B12 levels as well as 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotypes in 467 patients hospitalized with a first well-documented deep vein thrombosis and/or pulmonary embolism not related to a major acquired risk factor and 467 controls matched for gender and age. RESULTS: Mild hyperhomocysteinemia, low serum folates, and vitamin B12 were associated with VTE independently of each other. In multivariate analysis, odds ratios (OR) (95% CI) for VTE associated with mild hyperhomocysteinemia (>15 micromol L(-1)), low serum folates (< or = 4.9 nmol L(-1)), and vitamin B12 (< or = 253 pmol L(-1)) were 1.48 (1.05-2.08), 3.14 (1.35-7.32) and 1.42 (1.03-1.98), respectively. An MTHFRC677T genotype was not significantly associated with VTE; OR (95% CI): 1.13 (0.70-1.81) CONCLUSIONS: The current data provides further knowledge in the complex relationship between hyperhomocysteinemia, low vitamin levels, and VTE.
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Journal of Thrombosis and Haemostasis, Wiley, 2006, 4 (4), pp.793-9. 〈10.1111/j.1538-7836.2006.01856.x〉
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Contributeur : Ghislaine Calvez <>
Soumis le : jeudi 19 avril 2012 - 15:50:36
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

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Emmanuel Oger, Karine Lacut, Grégoire Le Gal, Francis Couturaud, D. Guénet, et al.. Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study.. Journal of Thrombosis and Haemostasis, Wiley, 2006, 4 (4), pp.793-9. 〈10.1111/j.1538-7836.2006.01856.x〉. 〈hal-00689449〉

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