Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons. - Université de Bretagne Occidentale Access content directly
Journal Articles Current HIV Research Year : 2007

Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons.

Abstract

In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAART-induced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process.
No file

Dates and versions

hal-00688279 , version 1 (17-04-2012)

Identifiers

  • HAL Id : hal-00688279 , version 1
  • PUBMED : 17504179

Cite

Luc de Saint Martin, Elisabeth Pasquier, Olivier Vandhuick, Bertrand Arnaud, Sophie Vallet, et al.. Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons.. Current HIV Research, 2007, 5 (3), pp.361-4. ⟨hal-00688279⟩
48 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More