Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons.

Luc De Saint Martin 1, 2, * Elisabeth Pasquier 1, 2 Olivier Vandhuick 3 Bertrand Arnaud 1 Sophie Vallet 4 Jérôme Duchemin 1 Véronique Bellein 2 Luc Bressollette 3
* Auteur correspondant
1 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
2 DMIP - Brest - Département de Médecine Interne et Pneumologie [Brest]
3 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
4 virology
Abstract : In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAART-induced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process.
Type de document :
Article dans une revue
Current HIV Research, Bentham Science Publishers, 2007, 5 (3), pp.361-4
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http://hal.univ-brest.fr/hal-00688279
Contributeur : Ghislaine Calvez <>
Soumis le : mardi 17 avril 2012 - 11:35:43
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

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  • HAL Id : hal-00688279, version 1
  • PUBMED : 17504179

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UNIV-BREST | GETBO

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Luc De Saint Martin, Elisabeth Pasquier, Olivier Vandhuick, Bertrand Arnaud, Sophie Vallet, et al.. Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons.. Current HIV Research, Bentham Science Publishers, 2007, 5 (3), pp.361-4. 〈hal-00688279〉

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