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Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons.

Abstract : In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAART-induced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process.
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https://hal.univ-brest.fr/hal-00688279
Contributor : Ghislaine Calvez <>
Submitted on : Tuesday, April 17, 2012 - 11:35:43 AM
Last modification on : Thursday, November 29, 2018 - 4:09:26 PM

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  • HAL Id : hal-00688279, version 1
  • PUBMED : 17504179

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Luc de Saint Martin, Elisabeth Pasquier, Olivier Vandhuick, Bertrand Arnaud, Sophie Vallet, et al.. Correlations between carotid IMT, factor VIII activity level and metabolic disturbances: a cardio-vascular risk factor in the HIV positive persons.. Current HIV Research, Bentham Science Publishers, 2007, 5 (3), pp.361-4. ⟨hal-00688279⟩

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