Skip to Main content Skip to Navigation
New interface
Journal articles

[Optimum duration of anticoagulant treatment after an episode of venous thromboembolism].

Abstract : Vitamin K antagonists are the mainstay for the treatment for venous thromboembolism. The optimum (VTE) course of oral anticoagulant therapy is determined according to the risk of recurrent VTE after stopping anticoagulant therapy and the risk of anticoagulant-related bleeding while on antivitamin K. The risk of recurrent VTE is low when the initial episode is provoked by a reversible major-risk factor (surgery), whereas this risk is high when VTE is not provoked or associated with a persistent-risk factor (cancer). Conversely, the influence of biochemical and morphological tests is uncertain. The optimum balance of the benefits and the risks of oral anticoagulant therapy is based on the frequency as well as the consequences of the risk of recurrent VTE and anticoagulant-related bleeding. After VTE provoked by a major reversible-risk factor, three months of anticoagulation is optimal, whereas after unprovoked VTE, anticoagulation should be extended. However, given the number of unresolved issues, a randomised trial comparing different durations of anticoagulation is needed.
Document type :
Journal articles
Complete list of metadata
Contributor : Ghislaine Calvez Connect in order to contact the contributor
Submitted on : Thursday, April 5, 2012 - 3:37:53 PM
Last modification on : Thursday, March 31, 2022 - 11:00:02 AM




Francis Couturaud, Clive Kearon. [Optimum duration of anticoagulant treatment after an episode of venous thromboembolism].. Revue de Pneumologie Clinique, 2008, 64 (6), pp.305-15. ⟨10.1016/j.pneumo.2008.09.007⟩. ⟨hal-00685646⟩



Record views