Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: role of drug induced homocysteinemia?

Karine Lacut 1, 2 Grégoire Le Gal 1, 2 Jean-Hervé Abalain 3 Dominique Mottier 1, 2 Emmanuel Oger 4
1 GETBO - Groupe d'Etude de la Thrombose de Bretagne Occidentale
2 CIC - Brest - Centre d'Investigation Clinique
3 JHA - Département de Biochimie et de Pharmaco-Toxicologie
4 Service de Pharmacologie
Abstract : BACKGROUND: Previous studies reported that statin use was associated with a decreased risk of venous thromboembolism (VTE), whereas no association was found between fibrate use and VTE. This report aims to test the hypothesis that part of these contrasting associations is related to total homocysteine level (tHcy). MATERIALS AND METHODS: This report from a case-control study included 677 cases hospitalised with confirmed VTE and no major acquired risk factor of VTE and their 677 controls. Statin and fibrate exposure was defined as a current use of drugs at admission. Fasting serum tHcy was measured in all patients. RESULTS: The estimated odds ratio for VTE related to statin use was 0.53 (CI 95% 0.37-0.78), whereas it was 1.88 (CI 95% 1.29-2.74) for fibrate use. No difference was found for tHcy levels between patients who were current users of statin compared to non users (17.7 micromol/L+/-7.3 in users vs 18.4 micromol/L+/-8.4 in non users, p=0.50). In contrast, fibrate users had a significant higher mean level of tHcy than non users (23.2 micromol/L+/-8.7 in users vs 18.4 micromol/L+/-8.4 in non users, p<0.0001). Nevertheless, adjustment on tHcy level did not alter significance and strength of the association between fibrates and VTE (1.66, CI 95% 1.07-2.59). CONCLUSIONS: Statin use was associated with a significant decreased risk of VTE, whereas fibrate use was associated with a significant increased risk of VTE. This last association was independent of tHcy levels.
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Article dans une revue
Thrombosis Research, Elsevier, 2008, 122 (3), pp.314-9. 〈10.1016/j.thromres.2007.10.014〉
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http://hal.univ-brest.fr/hal-00684131
Contributeur : Ghislaine Calvez <>
Soumis le : vendredi 30 mars 2012 - 16:01:44
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

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Karine Lacut, Grégoire Le Gal, Jean-Hervé Abalain, Dominique Mottier, Emmanuel Oger. Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: role of drug induced homocysteinemia?. Thrombosis Research, Elsevier, 2008, 122 (3), pp.314-9. 〈10.1016/j.thromres.2007.10.014〉. 〈hal-00684131〉

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