Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures

Matthieu Duchemin; Michel Auffret; Nathalie Wessel; Marlène Fortier; Yves Morin; Jocelyne Pellerin; Michel Fournier

doi:10.1016/j.envpol.2007.08.015

Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures

Matthieu Duchemin ^{1, 2} Michel Auffret ¹ Nathalie Wessel ¹ Marlène Fortier ² Yves Morin ² Jocelyne Pellerin ³ Michel Fournier ^{2, 3}

1 LEMAR - Laboratoire des Sciences de l'Environnement Marin (LEMAR)

2 INRS-IAF - Institut Armand Frappier

3 ISMER - Institut des Sciences de la MER de Rimouski

Abstract : Biological impairments due to mercury discharge into the environment are now an issue of global concern. From the three forms of mercury found in aquatic ecosystems, the immunotoxic effects of mercury chloride were examined in the model animal, the blue mussel. In order to investigate the toxic potency of this chemical, three exposure regimes were carried out: chronic exposure of groups of individuals, a new protocol "in tubo" designed for sub-acute exposures of individuals, and acute exposures of target cells. Chronic exposure revealed significant immunotoxic effects after 7 days at 10−6 M, while acute exposures showed significant inhibition of phagocytosis at 10−4 M and 10−3 M. In sub-acute exposures both circulating haemocytes and haemocyte mortality increased at 10−4 M and 10−3 M while phagocytosis and the clearance rate drew hormetic toxic effects on healthy individuals. These results suggest the use of the "in tubo" design for bivalve toxicological individual studies.

Keywords : Bivalve Immune system Mercury Individual exposure Clearance rate

Type de document :

Article dans une revue

Environmental Pollution, Elsevier, 2008, 153 (2), pp.416-423. 〈10.1016/j.envpol.2007.08.015〉

Domaine :

Sciences de l'environnement

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http://hal.univ-brest.fr/hal-00654320
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Soumis le : mercredi 21 décembre 2011 - 16:01:21
Dernière modification le : jeudi 20 septembre 2018 - 13:16:05

Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures

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Multiple experimental approaches of immunotoxic effects of mercury chloride in the blue mussel, Mytilus edulis, through in vivo, in tubo and in vitro exposures

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