Myotonic dystrophy type 1 BIOLOGIE MOLECULAIRE Neuron Maximal force Knockout Muscle Acetylcholinesterase knockout mouse Myotonic Dystrophy Type 1 Myotonic Dystrophy CTG repeat contractions Mice Astrocyte Dystrophie myotonique Glutamate Aging Acute coronary syndrome Brain dysfunction Centronuclear myopathy MBNL GSK3␤ AAV ACETYLCHOLINESTERASE Cell penetrating peptide Animals Transgenic mouse model DM1 Intermediate filament Heart failure CONGENITAL MYATHENIC SYNDROME RNA interference Dilated cardiomyopathy Antisense oligonucleotides RNA splicing Exercise RNA biology Mouse model Thérapie génique Autophagy Fibrosis CTG repeats Dystrophie Myotonique Brain GABA PacBio Expression Oligodendrocyte KNOCKOUT MICE Cardiac muscle Genotype phenotype correlation DMSXL mice Dystrophin Heart Myostatin Exercice Gene Therapy In vivo CTG repeat instability Trinucleotide repeat expansion Central nervous system Myotonic Dystrophy type 1 Motoneuron Muscular dystrophy Cell model Therapy Glucocorticoid-receptor Lc3 Skeletal muscle Myotonic dystrophy CMS Gene therapy Oligodendrocytes Dynamin 2 Myelin DMPK Desmin Cell culture model Humans Quantitative microdialysis Mouse models Long read sequencing ARN CRISPRi CRISPR/Cas9 Trinucleotide Repeat Expansion Acetylcholinesterase deficiency Gene editing Cytoskeleton Alternative splicing Transgenic mouse Diaphragm Antisense oligonucleotide Myotonic dystrophy mouse models Glial cells Duchenne muscular dystrophy Male Hypoxia Astrocytes Transcriptomics Glucocorticoids PCR