Team PhylHom, UMR MICALIS

The PhylHom team focuses on the human microbiome and the impact of xenobiotics (dietary and environmental exposures, drugs, etc) on these complex ecosystems, combining skills in microbial ecology, anaerobic microbiology, and meta-omics. The impact of exposures on the microbiome is determined in a range of health-associated and pathological conditions (neurodevelopment, prematurity, therapy response, inflammatory diseases, cancer, etc.) within translational research projects involving clinicians and epidemiologists.

We have developed an in-vitro pipeline to dynamically assess the impact of biotic and abiotic factors on the host-derived microbiomes. Additionally, we construct synthetic microbial communities from these samples under anaerobic conditions. Leveraging our expertise in microbial ecology across different ecosystems, we assemble relevant microbial microcosms to elucidate the effects of xenobiotics on microbiota, and consequently on human health. Furthermore, we propose modulation strategies such as nutritional interventions to prevent and/or mitigate detrimental outcomes.