Team MIHA, UMR MICALIS

The Microbiota Interactions with Human and Animal (MIHA) team at INRAE is interested in studying the interactions between the intestinal microbiota and its host and their role in digestive inflammation.

More specifically, we are focusing on analyzing the functions of the microbiome that are modulated in inflammatory conditions. In this context, the team is analyzing the key role of the proteolytic imbalance observed in patients with inflammatory bowel diseases and inflammatory bowel syndrome.

To this end, we are isolating genes and/or bacteria signatures that are associated to these diseases and are exploring their effects on the holobiont (host and its microbiota) response. We are also investigating the impact of food and diet as a source of proteases and antiproteases that could be used to restore proteolytic homeostasis.