Rwanda, in eastern tropical Africa, is a small, densely populated country where climatic disasters are often the cause of considerable damage and deaths. Landslides are among the most frequent hazards, linked to the country’s peculiar configuration including high relief with steep slopes, humid tropical climate with heavy rainfall, intense deforestation over the past 60 years, and extensive use of the soil for agriculture. The Karongi region, in the west-central part of the country, was affected by an exceptional cluster of more than 700 landslides during a single night (6–7 May 2018) over an area of 100 km2. We analyse the causes of this spectacular event based on field geological and geomorphology investigation and CHIRPS and ERA5-Land climate data. We demonstrate that (1) the notably steep slopes favoured soil instability; (2) the layered soil and especially the gravelly, porous C horizon allowed water storage and served as a detachment level for the landslides; (3) relatively low intensity, almost continuous rainfall over the previous two months lead to soil water-logging; and (4) acoustic waves from thunder or mechanical shaking by strong wind destabilized the water-logged soil through thixotropy triggering the landslides. This analysis should serve as a guide for forecasting landslide-triggering conditions in Rwanda.