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Article Dans Une Revue BMC Genomics Année : 2017

The emerging landscape of dynamic DNA methylation in early childhood

Cheng-Jian Xu
  • Fonction : Auteur
Marc Jan Bonder
  • Fonction : Auteur
Cilla Söderhäll
  • Fonction : Auteur
Mariona Bustamante
Ulrike Gehring
Soesma Jankipersadsing
  • Fonction : Auteur
Pieter van Der Vlies
  • Fonction : Auteur
Cleo van Diemen
  • Fonction : Auteur
Bianca van Rijkom
  • Fonction : Auteur
Inger Kull
  • Fonction : Auteur
Juha Kere
  • Fonction : Auteur
  • PersonId : 906747
Josep Maria Anto
  • Fonction : Auteur
Alexandra Zhernakova
  • Fonction : Auteur
Cisca Wijmenga
  • Fonction : Auteur
Jordi Sunyer
  • Fonction : Auteur
Erik Melen
  • Fonction : Auteur
Yang Li
Dirkje S. Postma
  • Fonction : Auteur
Gerard H. Koppelman
  • Fonction : Auteur

Résumé

BACKGROUND: DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood. RESULTS: By analysing 538 paired DNA blood samples from children at birth and at 4-5 years old and 726 paired samples from children at 4 and 8 years old from four European birth cohorts using the Illumina Infinium Human Methylation 450 k chip, we have identified 14,150 consistent age-differential methylation sites (a-DMSs) at epigenome-wide significance of p < 1.14 × 10-7. Genes with an increase in age-differential methylation were enriched in pathways related to 'development', and were more often located in bivalent transcription start site (TSS) regions, which can silence or activate expression of developmental genes. Genes with a decrease in age-differential methylation were involved in cell signalling, and enriched on H3K27ac, which can predict developmental state. Maternal smoking tended to decrease methylation levels at the identified da-DMSs. We also found 101 a-DMSs (0.71%) that were regulated by genetic variants using cis-differential Methylation Quantitative Trait Locus (cis-dMeQTL) mapping. Moreover, a-DMS-associated genes during early development were significantly more likely to be linked with disease. CONCLUSION: Our study provides new insights into the dynamic epigenetic landscape of the first 8 years of life.
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hal-01792686 , version 1 (26-05-2021)

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Cheng-Jian Xu, Marc Jan Bonder, Cilla Söderhäll, Mariona Bustamante, Nour Baïz, et al.. The emerging landscape of dynamic DNA methylation in early childhood. BMC Genomics, 2017, 18, pp.25. ⟨10.1186/s12864-016-3452-1⟩. ⟨hal-01792686⟩
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