Optimizing Communication on HPV Vaccination to Parents of 11- to 14-Year-Old Adolescents in France: A Discrete Choice Experiment - Epidémiologie clinique et évaluation économique appliquées aux populations vulnérables
Article Dans Une Revue The Patient - Patient-Centered Outcomes Research Année : 2024

Optimizing Communication on HPV Vaccination to Parents of 11- to 14-Year-Old Adolescents in France: A Discrete Choice Experiment

1 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
2 LIRAES (URP_ 4470) - Laboratoire Interdisciplinaire de Recherche Appliquée en Economie de la Santé
3 Service d'Infectiologie Unité de gestion du risque infectieux [Saint-Etienne]
4 GIMAP - Physiopathologie et biothérapies des infections muqueuses [CIRI]
5 CIC-EC 1408 - Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
6 ARENES - Arènes: politique, santé publique, environnement, médias
7 RSMS - Recherche sur les services et le management en santé
8 EHESP - École des Hautes Études en Santé Publique [EHESP]
9 SHS - Département des sciences humaines et sociales
10 Santé publique France - French National Public Health Agency [Saint-Maurice, France]
11 Faculté de Médecine Jacques Lisfranc [Université Saint-Etienne]
12 P2S - Parcours santé systémique
13 LIP-PC2S - Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social
14 CRCDC Pays de la Loire - Centre Régional de Coordination des Dépistages des Cancers [Angers]
15 ECEVE (U1123 / UMR_S_1123) - Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables
16 Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Hopital Robert Debre
17 SPHERE - MethodS in Patients-centered outcomes and HEalth ResEarch
18 CIC - Centre d’Investigation Clinique [Tours] CIC 1415
19 MPI - Département Méthodologie Promotion Investigation [CHRU Nancy]
20 APEMAC - Adaptation, mesure et évaluation en santé. Approches interdisciplinaires
21 METIS - Département Méthodes quantitatives en santé publique

Résumé

Background: With the aim to optimize communication during HPV vaccination campaigns in France, we elicited parental preferences around HPV vaccination. Methods: We conducted a single-profile discrete choice experiment (DCE) among parents of 11- to 14-year-old middle-school pupils, who completed an anonymous, self-administered, internet-based questionnaire during 2020-2021. The DCE comprised five attributes (vaccine-preventable disease, justification of optimal age, information on safety, indirect protection and coverage) of vaccination against an unnamed disease that were presented to respondents in ten choice tasks, or scenarios. We use fixed effect logit models to estimate attribute weights on theoretical vaccine acceptance, and random effect linear regression to estimate attribute coefficients on vaccine eagerness (decision and decision certainty). We estimated marginal effects of attributes on expected vaccine acceptance. Results: Vaccination scenarios were accepted by 55.6-89.2% of the 1291 participants. The largest marginal effects on expected vaccine acceptance in the full sample arose from prevention of cancer versus genital warts (+ 11.3 percentage points); from a "severe side effect suspicion that was not scientifically confirmed" versus a statement about "more benefits than risks" (+ 8.9 percentage points), and information on 80% vaccine coverage in neighbouring countries versus on "insufficient coverage" (+ 4.2 percentage points). Explaining the early age of vaccination by sexual debut had a strong negative impact among French monolingual parents with lower education level (vs age-independent, OR 0.48, 95% CI 0.27-0.86), but not other socio-economic groups. After removing low-quality responses (unvaried certainty and short questionnaire completion), among serial non-demanders with children not vaccinated against HPV, only disease elimination impacted vaccine eagerness positively (coefficient 0.54, 0.06-1.02). Discussion: Using DCEs to elicit parents' preferences around communication messages, notably on cancer prevention, vaccine coverage and information about vaccine safety, could help to optimize HPV vaccination promotion efforts.
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hal-04578136 , version 1 (06-08-2024)

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Sandra Chyderiotis, Jonathan Sicsic, Amandine Gagneux-Brunon, Jocelyn Raude, Anne-Sophie Barret, et al.. Optimizing Communication on HPV Vaccination to Parents of 11- to 14-Year-Old Adolescents in France: A Discrete Choice Experiment. The Patient - Patient-Centered Outcomes Research, 2024, 17 (5), pp.575-588. ⟨10.1007/s40271-024-00687-6⟩. ⟨hal-04578136⟩
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