A Coordination Chemistry Approach to Fine-Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications

Abstract : The geometric features of two pyclen-based ligands possessing identical donor atoms but different site organization have a profound impact in their complexation properties toward lanthanide ions. The ligand containing two acetate groups and a picolinate arm arranged in a symmetrical fashion (L1) forms a Gd3+ complex being two orders of magnitude less stable than its dissymmetric analogue GdL2. Besides, GdL1 experiences a much faster dissociation following the acid-catalyzed mechanism than GdL2. On the contrary, GdL1 exhibits a lower exchange rate of the coordinated water molecule compared to GdL2. These very different properties are related to different strengths of the Gd ligand bonds associated to steric effects, which hinder the coordination of a water molecule in GdL2 and the binding of acetate groups in GdL1.
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Chemistry - A European Journal, Wiley-VCH Verlag, A Paraître, 〈10.1002/chem.201705528〉
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http://hal.univ-brest.fr/hal-01665222
Contributeur : Nicolas Renard <>
Soumis le : vendredi 15 décembre 2017 - 15:58:52
Dernière modification le : jeudi 11 janvier 2018 - 06:17:07

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Mariane Le Fur, Eniko Molnar, Maryline Beyler, Ferenc Kalman, Olivier Fougère, et al.. A Coordination Chemistry Approach to Fine-Tune the Physicochemical Parameters of Lanthanide Complexes Relevant to Medical Applications. Chemistry - A European Journal, Wiley-VCH Verlag, A Paraître, 〈10.1002/chem.201705528〉. 〈hal-01665222〉

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