Glyco-phospho-glycero-ether lipid as modulator of SK3 ion channel and SK3-dependent cancer cell migration

Abstract : In this short review paper, we report our efforts to design new inhibitors of SK3 ion channel that are involved in cancer cell migration and metastases formation. The originality of the new SK3 inhibitors comes from their amphiphilic nature and contrast form others inhibitors that are peptides or heterocyclic compounds. We found that ether lipids and ether phospho-glyco-lipids are indeed efficient to modulate SK3 ion channel that consequently reduced cancer cell migration (in vitro assays) and abolished the formation of bone metastases in a murine model of breast cancer.
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Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 2016, 191 (11-12), pp.1623 - 1624. 〈http://www.tandfonline.com/doi/full/10.1080/10426507.2016.1217221〉. 〈10.1080/10426507.2016.1217221〉
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http://hal.univ-brest.fr/hal-01539329
Contributeur : Nicolas Renard <>
Soumis le : mercredi 14 juin 2017 - 16:26:52
Dernière modification le : jeudi 11 janvier 2018 - 06:17:06

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C. Sevrain, Wilfried Berthe, Hélène Couthon, J. P. Haelters, M. Bouchet, et al.. Glyco-phospho-glycero-ether lipid as modulator of SK3 ion channel and SK3-dependent cancer cell migration. Phosphorus, Sulfur, and Silicon and the Related Elements, Taylor & Francis, 2016, 191 (11-12), pp.1623 - 1624. 〈http://www.tandfonline.com/doi/full/10.1080/10426507.2016.1217221〉. 〈10.1080/10426507.2016.1217221〉. 〈hal-01539329〉

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