A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry

Abstract : A tandem mass spectrometry-based method is developed to determine the degree of purity achieved in the cyclization of a linear poly(L-lactide) prepared by copper-catalyzed alkyne-azide cycloaddition. When proton nuclear magnetic resonance, size-exclusion chromatography, and single-stage mass spectrometry are unable to demonstrate the presence of a residual linear polymer, the proposed ESI-tandem mass spectrometry methodology allows detection of starting material traces (<5%) based on radically different collision-induced dissociation (CID) behaviours. The technique is believed to be readily adaptable to numerous isomeric pairs of macromolecules presenting different CID characteristics.
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Article dans une revue
Polymer Chemistry, Royal Society of Chemistry - RSC, 2014, 6 (1), pp.64 - 69. 〈http://pubs.rsc.org/en/Content/ArticleLanding/2015/PY/C4PY01087F#!divAbstract〉. 〈10.1039/C4PY01087F〉
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http://hal.univ-brest.fr/hal-01538525
Contributeur : Nicolas Renard <>
Soumis le : mardi 13 juin 2017 - 16:30:20
Dernière modification le : jeudi 11 janvier 2018 - 06:17:06

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Thomas Josse, Julien De Winter, Philippe Dubois, Olivier Coulembier, Pascal Gerbaux, et al.. A tandem mass spectrometry-based method to assess the architectural purity of synthetic polymers: a case of a cyclic polylactide obtained by click chemistry. Polymer Chemistry, Royal Society of Chemistry - RSC, 2014, 6 (1), pp.64 - 69. 〈http://pubs.rsc.org/en/Content/ArticleLanding/2015/PY/C4PY01087F#!divAbstract〉. 〈10.1039/C4PY01087F〉. 〈hal-01538525〉

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