Functionalized Phospholipid Molecular Platform: Use for Production of Cationic Fluorescent Lipids

Abstract : Fluorescent amphiphilic phospholipids (neutral or cationic) in which fluorescent probes are contained in the lipid domain were synthesized via phosphoramide intermediates possessing two distinct lipid chains. One of these lipid chains is ω-functionalized with an azide or alkyne group, and this is subsequently used to introduce a fluorescent probe by Huisgen cycloaddition. Five different fluorescent probes (naphthalimide, dansyl, fluoresceine, Nile red, and coumarin) were considered in this study. These neutral and cationic fluorescent lipids were included at a 1 % molar ratio with a selected cationic lipid (KLN47) to produce liposomal solutions that were characterized by dynamic light scattering and zeta potential measurements.
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European Journal of Organic Chemistry, Wiley-VCH Verlag, 2014, 2014 (5), pp.1076 - 1083. 〈http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201301416/abstract〉. 〈10.1002/ejoc.201301416〉
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http://hal.univ-brest.fr/hal-01531037
Contributeur : Nicolas Renard <>
Soumis le : jeudi 1 juin 2017 - 10:53:57
Dernière modification le : jeudi 11 janvier 2018 - 06:17:06

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Mathieu Berchel, Jean-Pierre Haelters, Damien Afonso, Alicia Maroto, Laure Deschamps, et al.. Functionalized Phospholipid Molecular Platform: Use for Production of Cationic Fluorescent Lipids. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2014, 2014 (5), pp.1076 - 1083. 〈http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201301416/abstract〉. 〈10.1002/ejoc.201301416〉. 〈hal-01531037〉

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