[Regulatory lymphocytes: a new cooperation between T and B cells for a better control of the immune response].

Abstract : Mechanims of peripheral tolerance include molecular controls and the presence of regulatory lymphocytes. Regulatory T lymphocytes (Tregs) correspond to different sub-populations of T cells that control immune responses due to the production of cytokines, such as IL-10 and with direct cell-to-cell contacts. Tregs targets are antigen presenting cells, such as dendritic cells, effector CD4(+) and CD8(+) lymphocytes but also effector antibody-producing B lymphocytes. Regulatory B lymphocytes (Bregs) have been more recently described and likely represent different sub-populations of B cells that control the development of autoimmune and inflammatory diseases due to the production of IL-10 and using intercellular contacts. Bregs targets encompass all the cells involved in the immune responses which are thus under a dual control by regulatory lymphocytes. Development and efficient activity of Tregs appear dependent of Bregs for a better regulation of autoimmune reactions, of anti-infectious reactions, but also of anti-tumor reactions.
Type de document :
Article dans une revue
La Presse medicale, Paris, Masson et Cie, 2014, 43 (1), pp.18-26. 〈10.1016/j.lpm.2013.02.332〉
Liste complète des métadonnées

http://hal.univ-brest.fr/hal-00957388
Contributeur : Geneviève Michel <>
Soumis le : lundi 10 mars 2014 - 12:16:58
Dernière modification le : mercredi 29 novembre 2017 - 14:53:44

Identifiants

Collections

Citation

Christophe Jamin, Achouak Achour, Pierre Youinou, Jacques-Olivier Pers. [Regulatory lymphocytes: a new cooperation between T and B cells for a better control of the immune response].. La Presse medicale, Paris, Masson et Cie, 2014, 43 (1), pp.18-26. 〈10.1016/j.lpm.2013.02.332〉. 〈hal-00957388〉

Partager

Métriques

Consultations de la notice

45