Twelve month clinical and angiographic outcome after stenting of unprotected left main coronary artery stenosis with paclitaxel-eluting stents--results of the multicentre FRIEND registry.

Abstract : AIMS: To evaluate the angiographic and clinical outcome of patients undergoing paclitaxel-eluting stent (PES) implantation for unprotected left main coronary artery (ULMCA) stenosis in a multicentre, prospective registry. The overall event rate for PCI of ULMCA disease remains higher than in on-label use making additional outcome data and risk-stratification tools for the ULMCA population desirable. METHODS AND RESULTS: A prospective registry included all patients with a significant (> 50%) stenosis in ULMCA disease. In 151 of these patients the target lesion involved the distal bifurcation in 100 patients (66%), which was treated by predominantly using a "provisional T stenting" strategy. In distal ULMCA disease group, 72% had only one stent implantation while 28% had multiple (either 2 or 3) stents implanted. At a median follow-up of 472 +/- 75 days, cardiac death occurred in 3 patients (2%) and major adverse cardiac and cerebrovascular events (MACCE) in 16 patients (10.6%). CONCLUSIONS: In the drug-eluting stent era, paclitaxel eluting stent implantation of ULMCA stenosis provided excellent immediate and mid-term results in this selected population, suggesting that it may be considered as a safe and effective alternative to CABG for selected patients with ULMCA who are treated in institutions performing large numbers of PCI procedures.
Type de document :
Article dans une revue
EuroIntervention, 2009, 4 (4), pp.449-56
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http://hal.univ-brest.fr/hal-00837626
Contributeur : François Guerrero <>
Soumis le : dimanche 23 juin 2013 - 18:12:45
Dernière modification le : jeudi 11 janvier 2018 - 06:15:41

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  • HAL Id : hal-00837626, version 1
  • PUBMED : 19284066

Citation

Didier Carrié, Hélène Eltchaninoff, Thierry Lefèvre, Marc Silvestri, Gilles Levy, et al.. Twelve month clinical and angiographic outcome after stenting of unprotected left main coronary artery stenosis with paclitaxel-eluting stents--results of the multicentre FRIEND registry.. EuroIntervention, 2009, 4 (4), pp.449-56. 〈hal-00837626〉

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