TLR9 responses of B cells are repressed by intravenous immunoglobulin through the recruitment of phosphatase.

Abstract : One way for intravenous Ig (IVIg) to affect responses of the B cells might be to operate through their TLR7 and TLR9. We confirm the ability of TLR agonists to induce CD25 expression in B cells. For this to occur, sialylated Fc-gamma of IgG included in the IVIg preparation are required. As a result, IVIg suppresses TLR-induced production of the proinflammatory IL-6, but not that of the anti-inflammatory IL-10. That is, IVIg mimics the effects of the MyD88 inhibitor. Finally, as we previously showed that IVIg induces CD22 to recruit the inhibitory SHP-1, we established that this enzyme was also involved in IVIg-induced inhibition of TLR9 signaling. This is the first report to demonstrate such a mechanism underlying the negative impact of IVIg on B lymphocytes.
Type de document :
Article dans une revue
Journal of Autoimmunity, Elsevier, 2011, 37 (3), pp.190-7. 〈10.1016/j.jaut.2011.05.014〉
Liste complète des métadonnées

http://hal.univ-brest.fr/hal-00771231
Contributeur : Geneviève Michel <>
Soumis le : mardi 8 janvier 2013 - 11:28:26
Dernière modification le : mercredi 29 novembre 2017 - 14:53:52

Identifiants

Collections

Citation

Jean-François Séité, Thomas Guerrier, Divi Cornec, Christophe Jamin, Pierre Youinou, et al.. TLR9 responses of B cells are repressed by intravenous immunoglobulin through the recruitment of phosphatase.. Journal of Autoimmunity, Elsevier, 2011, 37 (3), pp.190-7. 〈10.1016/j.jaut.2011.05.014〉. 〈hal-00771231〉

Partager

Métriques

Consultations de la notice

82