Pathophysiological cytokine network in primary Sjogren's syndrome

Abstract : The continuing progress in discovering lymphocyte subsets and the lengthening list of cytokines involved, together with how they are affected in primary Sjogren's syndrome (pSS), has further fuelled the debate on pSS pathogenesis. In this review the "interferon signature" observed in the salivary glands and the role of T-cell derived cytokines (Th1/Th2 polarization, Th17 and regulatory T cells) will be discussed. A particular emphasis has been placed on the B-cell derived cytokines and especially on FLT3-Ligand, a cytokine associated with lymphoma in pSS, and B-cell activating factor (BAFF) that prevents apoptosis of autoreactive B cells. It has indeed become a challenge to understand how the interaction between several interconnected networks of cytokines impact so different cell population in the immunopathogenesis of pSS.
Type de document :
Article dans une revue
La Presse medicale, Paris, Masson et Cie, 2012, 41, pp.e467-e474. 〈10.1016/j.lpm.2012.04.029〉
Liste complète des métadonnées

http://hal.univ-brest.fr/hal-00769768
Contributeur : Geneviève Michel <>
Soumis le : jeudi 3 janvier 2013 - 12:07:07
Dernière modification le : mercredi 29 novembre 2017 - 14:53:50

Identifiants

Collections

Citation

Jacques-Olivier Pers, Ayan Lahiri, Gabriel J. Tobon, Pierre Youinou. Pathophysiological cytokine network in primary Sjogren's syndrome. La Presse medicale, Paris, Masson et Cie, 2012, 41, pp.e467-e474. 〈10.1016/j.lpm.2012.04.029〉. 〈hal-00769768〉

Partager

Métriques

Consultations de la notice

59