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Article Dans Une Revue Autoimmunity Reviews Année : 2012

CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte

Résumé

CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology and responses. Our recent studies have revealed that CD5 promotes constitutive activation of multiple signaling pathways including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT signaling pathways. Further, changes in cytokine production including the production of IL-10 are related to the activation of the transcription factors NFAT2 and STAT3. All in all, these studies provide a framework for understanding how CD5 impacts B lymphocyte biology and responses.

Domaines

Immunologie

Dates et versions

hal-00769761 , version 1 (03-01-2013)

Identifiants

Citer

R.A Mageed, Soizic Garaud, Taher E Taher, Kaushal Parikh, Jacques-Olivier Pers, et al.. CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte. Autoimmunity Reviews, 2012, pp.795-798. ⟨10.1016/j.autrev.2012.02.007⟩. ⟨hal-00769761⟩

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