Association of postmenopausal hormone replacement therapy with carotid atherosclerosis and soluble thrombomodulin: the vascular aging (EVA) study. Etude du Vieillissement Artériel.

Abstract : Hormone replacement therapy (HRT) may reduce atherosclerosis among postmenopausal women, partly by reducing vascular endothelium damage. We have tested this hypothesis by evaluating the association of HRT with firstly, carotid intima media thickness (IMT) and plaques, and secondly, with endothelial cell damage, indicated by soluble thrombomodulin (sTM). Then, we tested the association between the two markers of atherosclerosis and the levels of sTM. Among 747 postmenopausal women included into the EVA study, we compared 154 HRT users (including 80% transdermal treatment) with 593 never users. Carotid IMT and plaques were measured with B-mode ultrasonography and sTM with ELISA. At least one plaque was detected among 13.6% of HRT users and 27.3% of never users. After adjustment for confounding factors, the odds ratio for the presence of plaque was 0.45 (95% confidence interval, 0.25-0.78, P=0.005) in HRT users in comparison with nonusers. HRT users had a slightly lower crude mean IMT than nonusers, but the difference was not significant. sTM was positively associated with mean IMT (P for trend=0.001) but not with plaques. Finally, estrogen users had a lower sTM level than nonusers (difference 0.14 ng/ml, P=0.03). As HRT was associated with sTM and plaques, but not with IMT, while sTM was only associated with IMT, our hypothesis was not confirmed. This suggests that the possible beneficial effects of HRT on atherosclerosis may not go through the endothelial cell damage assessed by plasma thrombomodulin.
Type de document :
Article dans une revue
Thrombosis Research, Elsevier, 2002, 105 (4), pp.291-7
Liste complète des métadonnées

http://hal.univ-brest.fr/hal-00722274
Contributeur : Ghislaine Calvez <>
Soumis le : mercredi 1 août 2012 - 10:38:12
Dernière modification le : mercredi 10 janvier 2018 - 14:42:02

Identifiants

  • HAL Id : hal-00722274, version 1
  • PUBMED : 12031822

Collections

Citation

Laure Petit, Floor V A Van Oort, Grégoire Le Gal, Louise I Mennen, Martine Alhenc-Gelas, et al.. Association of postmenopausal hormone replacement therapy with carotid atherosclerosis and soluble thrombomodulin: the vascular aging (EVA) study. Etude du Vieillissement Artériel.. Thrombosis Research, Elsevier, 2002, 105 (4), pp.291-7. 〈hal-00722274〉

Partager

Métriques

Consultations de la notice

54