VIDAS D-dimer in combination with clinical pre-test probability to rule out pulmonary embolism. A systematic review of management outcome studies. - Université de Bretagne Occidentale Accéder directement au contenu
Article Dans Une Revue Thrombosis and Haemostasis Année : 2009

VIDAS D-dimer in combination with clinical pre-test probability to rule out pulmonary embolism. A systematic review of management outcome studies.

Marc Carrier
Marc Righini
Reza Karami Djurabi
  • Fonction : Auteur
Menno V Huisman
  • Fonction : Auteur
Marc Rodger
  • Fonction : Auteur
Walter A Wuillemin
  • Fonction : Auteur

Résumé

Clinical outcome studies have shown that it is safe to withhold anticoagulant therapy in patients with suspected pulmonary embolism (PE) who have a negative D-dimer result and a low pretest probability (PTP) either using a PTP model or clinical gestalt. It was the objective of the present study to assess the safety of the combination of a negative VIDAS D-dimer result in combination with a non-high PTP using the Wells or Geneva models to exclude PE. A systematic literature search strategy was conducted using MEDLINE, EMBASE, the Cochrane Register of Controlled Trials and all EBM Reviews. Seven studies (6 prospective management studies and 1 randomised controlled trial) reporting failure rates at three months were included in the analysis. Non-high PTP was defined as "unlikely" using the Wells' model, or "low/intermediate" PTP using either the Geneva score, the Revised Geneva Score, or clinical gestalt. Two reviewers independently extracted data onto standardised forms. A total of 5,622 patients with low/intermediate or unlikely PTP were assessed using the VIDAS D-dimer. PE was ruled out by a negative D-dimer test in 2,248 (40%, 95% confidence intervals [CI] 38.7 to 41.3%) of them. The three-month thromboembolic risk in patients left untreated on the basis of a low/intermediate or unlikely PTP and a negative D-dimer test was 3/2,166 (0.14%, 95% CI 0.05 to 0.41%). In conclusion, the combination of a negative VIDAS D-dimer result and a non-high PTP effectively and safely excludes PE in an important proportion of outpatients with suspected PE.
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Dates et versions

hal-00683229 , version 1 (28-03-2012)

Identifiants

  • HAL Id : hal-00683229 , version 1
  • PUBMED : 19404542

Citer

Marc Carrier, Marc Righini, Reza Karami Djurabi, Menno V Huisman, Arnaud Perrier, et al.. VIDAS D-dimer in combination with clinical pre-test probability to rule out pulmonary embolism. A systematic review of management outcome studies.. Thrombosis and Haemostasis, 2009, 101 (5), pp.886-92. ⟨hal-00683229⟩
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